Rand Report: Preparedness of the U.S. Health Care System Infrastructure for an Alzheimer’s Treatment
Link to the report home page, summary, and PDFs of the full report.
Disclosing Amyloid Status in an Alzheimer’s Prevention Trials – First A4 Study Disclosure Results Published in JAMA Neurology
From the accompanying JAMA Neurology editorial “What is clear is that, with the advance of molecular diagnostic tools in neurology, clinicians and investigators will increasingly be faced with the challenge of presenting patients with information of uncertain prognostic significance. The investigators of the A4 study are to be commended for developing a thoughtful process of…
DetailsLSD1 Protects Against Hippocampal and Cortical Neurodegeneration
Alan Levey, MD, PhD, Director of Emory’s Alzheimer’s Disease Research Center, commented on the findings making news: “We were amazed to see the accumulation of LSD1 in neurofibrillary tangles in Alzheimer’s, and in TDP-43 aggregates in FTD” (Published in Nature Communications this week)
Axovant’s interpirdine fails to meet the trial’s primary endpoints. Read the Alzheimer’s Forum interpirdine report
What potential therapy reports out next? There are not a lot of large, late stage, Alzheimer’s trial results expected until 2019 (including Biogen’s aducanumab, Merck’s BACE- oriented verubecestat, and Lilly/AstraZeneca’s lanabecestat).
In Nature this week: Blocking ApoE4 in brain may prevent nerve cell death, inflammation
“Our results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-β pathology. ApoE4 exerts a ‘toxic’ gain of function whereas the absence of ApoE is protective” David Holtzman, MD Washington University
NYU’s EXERT Study Principal Investigator Martin Sadowski, MD, PhD wants to be able to write a prescription for exercise
Dr Sadowski talks about the potential of the EXERT Study to help identify the right dose of exercise to offset memory loss for people at risk for Alzheimer’s disease
Biohaven and Alzheimer’s Disease Cooperative Study (ADCS) Announce Phase 2 Clinical Trial Collaboration Evaluating Glutamate Modulating Agent Trigriluzole In Patients With Mild-To-Moderate AD.
The Biohaven Pharmaceutical Holding Company Ltd. announced today its clinical trial collaboration with the Alzheimer’s Disease Cooperative Study (ADCS).
STAT reports on the hunt for a new Alzheimer’s gene!
A family with an astonishing rate of Alzheimer’s disease may harbor a powerful new gene.
Big data in Alzheimer’s: Are women more vulnerable to Alzheimer’s disease than men?
JAMA Neurology reports on the differences in carriers of the “most potent genetic risk factor for Alzheimer’s disease” – the apolipoprotein E ε4 (APOE4) allele.
NIA Director Richard Hodes outlines the new NIH Alzheimer’s bypass budget
Presented, the Fiscal Year 2019 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias. Outlined at the July 28 meeting of the HHS Secretary’s Advisory Council on Alzheimer’s Research, Care, and Services.