What’s next in the Raskind/Peskind Prazosin research? They are directing the ADCS’ Peace AD trial which will test Prazosin, as a treatment for disruptive agitation, in people with moderate to severe Alzheimer’s disease. The trial is launching this spring in over 20 memory and long term care communities in the US.
The AlzForum’s editorial team provides a comprehensive recap of the last year in Alzheimer’s research and related public policy developments.
The updated guidelines reflect increased MCI research, the significance of MCI in clinical practice, and therapeutics in trials.
Rand Report: Preparedness of the U.S. Health Care System Infrastructure for an Alzheimer’s Treatment
Link to the report home page, summary, and PDFs of the full report.
Disclosing Amyloid Status in an Alzheimer’s Prevention Trials – First A4 Study Disclosure Results Published in JAMA Neurology
From the accompanying JAMA Neurology editorial “What is clear is that, with the advance of molecular diagnostic tools in neurology, clinicians and investigators will increasingly be faced with the challenge of presenting patients with information of uncertain prognostic significance. The investigators of the A4 study are to be commended for developing a thoughtful process of…
Alan Levey, MD, PhD, Director of Emory’s Alzheimer’s Disease Research Center, commented on the findings making news: “We were amazed to see the accumulation of LSD1 in neurofibrillary tangles in Alzheimer’s, and in TDP-43 aggregates in FTD” (Published in Nature Communications this week)
Axovant’s interpirdine fails to meet the trial’s primary endpoints. Read the Alzheimer’s Forum interpirdine report
What potential therapy reports out next? There are not a lot of large, late stage, Alzheimer’s trial results expected until 2019 (including Biogen’s aducanumab, Merck’s BACE- oriented verubecestat, and Lilly/AstraZeneca’s lanabecestat).
“Our results demonstrate that ApoE affects tau pathogenesis, neuroinflammation, and tau-mediated neurodegeneration independently of amyloid-β pathology. ApoE4 exerts a ‘toxic’ gain of function whereas the absence of ApoE is protective” David Holtzman, MD Washington University