The ADCS and the Mission of this Initiative

The Alzheimer’s Disease Cooperative Study (ADCS) at the University of California, San Diego (UCSD) is currently seeking letters of intent for combination therapy initiatives that address a spectrum of disease targets and mechanisms in Alzheimer’s Disease (AD). Combining multiple drugs or designing treatments that include a combination of pharmacological and lifestyle interventions that target multiple pathways could be an effective therapeutic approach, and aligns with the NIH Research Implementation Milestones as well as Alzheimer’s Association (AA) priorities.


This initiative focuses on cutting-edge projects primed for clinical trial. The intent of this program is to establish a collaboration with the ADCS to accelerate successful, external peer-reviewed grant applications to fund proof of concept multi-site combination therapy trials. Of particular interest are proposals that have promising single-site pilot or phase I data available to support the application.

Major Strategic Priorities

Major strategic priorities include but are not limited to multi-modal interventions that include a combination of any of the following:

  • Non-pharmacological lifestyle interventions (i.e. sleep, social engagement, exercise, cognitive training)
  • Repurposed compounds
  • Natural products
  • Novel candidates
  • Existing treatments for AD in combination with any of the above

Projects that include only a single drug or non-pharmacological candidate are welcome with the understanding that we will work to identify other promising candidates to evaluate in combination.

Please download the complete guidance document for more details

Deadlines and Contact Information

This call for LOIs is open until further notice. Feel free to verify with the Project Lead.

Selected ideas will be invited to submit a more detailed proposal for presentation to an Intervention Selection Committee before beginning the development of a grant proposal to the appropriate agency.

Please reach out with questions to ADCS Co-Director, Judy Pa ( or Project Lead, Michelle Herman (