ADCS Home

Welcome to the ADCS at UC San Diego

The Alzheimer’s Disease Cooperative Study (ADCS) is a progressive, multi-site clinical research consortium created to provide an operational framework for clinical trials, prospective cohort studies, and big data initiatives that focus on Alzheimer's disease, dementia risk, and brain health.

Donate to the ADCS

Current Programs

BenfoTeam Study

The BenfoTeam Study tests if increasing thiamine in the blood slows cognitive decline in people with early Alzheimer’s disease, including Mild Cognitive Impairment (MCI) and mild dementia.

Gene Therapy Program

The goal of the Epstein Family Alzheimer's Research Collaboration Gene Therapy Program (GTP) is to achieve a successful gene therapy treatment for Alzheimer’s disease in people living with the Jalisco PSEN1 mutation.

Powder for Pennies

The Epstein Family Alzheimer's Research Collaboration Powder for Pennies (P4P) Program aims to create a unique incubator and screening platform to test an array of single and combinatorial repurposed medicines and natural products in clinical trials for the treatment and prevention of Alzheimer’s disease.

Virtual Reality Brain Health Study

The Virtual Reality Brain Health Study is a novel study that uses three methods of lifestyle intervention involving physical exercise and Virtual Reality to promote brain health and cognition in older adults.

Asian Cohort for Alzheimer’s Disease

The Asian Cohort for Alzheimer’s Disease (ACAD) is an international collaboration with the goal of compiling a robust sample size of Asian American and Canadian subjects for Alzheimer’s disease research.

CAN-THUMBS UP

The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia – CAN-THUMBS UP (CTU) is a group of over 100 Canadian researchers within the Canadian Consortium on Neurodegeneration in Aging focused on dementia prevention. The CTU platform was initiated in 2019 and is part of the World Wide FINGERS prevention initiative.

Longitudinal Menopause Project

The goal of the Longitudinal Menopause Project (LMP) is to generate one of the most detailed examinations of brain health and menopause in the US to date. Recruitment will begin in Fall 2026 for women ages 40–55.

CARE study

CARE: Cutting Alzheimer’s Risk through Endocrinology, is a new $50 million program focused on the intersection of neuroendocrine risks and neurodegeneration to cut Alzheimer’s risk for women in half.

Other Resources

UC San Diego Multi Modal Imaging Lab
UC San Diego Brain TV