Eyes on the prize: Federal Alzheimer’s research effort aims to facilitate interventions It is fitting that this issue of Alzheimer’s & Dementia honors the life and work of our friend and colleague, Dr. Leon Thal. Leon’s research career, in important and perhaps some surprising ways.

It is inspired by the legacy of our friend and colleague Leon Thal, whose innovative and collaborative approach to scientific research serves as a guidepost as we move toward the discovery of new and effective ways to prevent AD or slow its progression. This article describes the progress to date and potentially promising areas of…

Recent Advances in AD Neurobiology

By Michael Rafii, M.D., Ph.D, ADCS Associate Medical Director Among the major uncertainties surrounding Alzheimer’s disease is whether and how the amyloid plaques found in the brains of patients with the disorder actually damage neurons. There are many theories; below are two of the leading ideas.   Calcium Overload Calcium ions play an essential role…

Why the Amyloid Hypothesis is Alive and Well

By Paul Aisen, M.D. Director, Alzheimer’s Disease Cooperative Study Professor of Neurosciences, University of California San Diego There has been much discussion in the news lately as to whether the amyloid hypothesis is the correct path for research. The amyloid hypothesis is supported by a huge body of evidence, but to my thinking the most…

Study Finds Improved Cognitive Health among Older Americans Rates of cognitive impairment among older Americans are on the decline, according to a new study supported by the National Institutes of Health (NIH) comparing the cognitive health of older people in 1993 and 2002.

Rates of cognitive impairment among older Americans are on the decline, according to a new study supported by the National Institutes of Health (NIH) comparing the cognitive health of older people in 1993 and 2002. Higher levels of education were associated with better cognitive health.