The NOBLE Study: A New Study for People with Mild to Moderate Alzheimer's Disease

Ongoing Study; Not Open for Enrollment

NOBLE is a clinical study to evaluate an investigational drug for patients with mild to moderate Alzheimer’s disease. Participants will receive the study drug or a placebo. During this study, if you are already taking medication for Alzheimer’s disease, you will probably continue to take it along with the study drug or placebo. The investigational drug may work by protecting brain cells which could result in improved memory. But, this has not been proven yet. We are doing this study to find out if this is true.

The study will enroll 450 patients with mild to moderate Alzheimer’s disease at many research sites across the United States. Total participation time is about 14 months, which includes screening, about one year of study treatment, and follow up to check safety.

You will be screened to see if you are eligible to participate. Screening includes tests like EKG, blood and urine exams, physical examination, and cognitive testing. Upon enrollment in the study, you will have a 1/3 chance of receiving the low dose of study drug, the high dose of study drug or placebo. Study participants will be seen by researchers every 4 weeks for the first 3 months, then every 6 to 8 weeks for the next 9 months, with a follow up visit 4 weeks later. Cognitive and physical evaluations and blood testing will be conducted at each visit. An MRI scan of the brain will be done at the beginning and end of the study.

Regularly scheduled physician visits are not disrupted by the study. Primary care physicians will be kept informed of your progress and laboratory results. You will also receive regular health assessments by health care professionals who specialize in Alzheimer’s disease.

Your participation is critical for developing effective treatments. People who have Alzheimer’s disease are urgently needed to aid researchers in finding new approaches

Selected eligibility criteria:

  • Women and men aged 55-85 years old with mild to moderate Alzheimer’s Disease
  • Receiving donepezil (Aricept®) or rivastigmine (Exelon® Patch) treatment for at least six months
  • Living in the community (not nursing homes)
  • Have a study partner that has regular contact with you about 10 hours per week and who will come to study visits with you
  • Weight of no more than 220 pounds

This study is sponsored by Toyama Chemical Co., Ltd and is being conducted by the Alzheimer’s Disease Cooperative Study (ADCS).

The NOBLE Study Locations


State City Site Contact Telephone Email
AZ Phoenix Banner Alzheimer’s Institute Dawn Batchuluun (602)839-4897
AZ Sun City Banner Sun Health Research Institute Sherye Sirrel (623)832-6522
AZ Tucson Arizona Health Sciences Center Derek Gin (520)626-9064
CA Fullerton Neurology Center of North Orange County Sheraz Mossa (714)879-7200 ext 106
CA La Jolla University of California, San Diego Victoria Shokrollah (858)246-1303
CA Orange University of California, Irvine – Neuropsychiatric Center Farah Toullier (714)456-7994
CT Hamden Geriatric and Adult Psychiatry Andrea DeClement (203)288-0414
CT New Haven Yale University School of Medicine Julia McDonald (203)764-8100
CT Norwalk Research Center for Clinical Research, Inc. Kinjalben Patel (203)838-0070
DC Washington Georgetown University Maysa Jawdat (202)687-8800
FL Hollywood Infinity Clinical Research, LLC Jorge Riveros (954)366-0277
FL Miami University of Miami Carmen Perez (305)243-0184
FL Miami Beach Wien Center for Clinical Research Rosemarie Rodriguez (305)674-2121 ext 56771
FL Ocala Renstar Medical Research Linda Mazur (352)629-5800
GA Atlanta NeuroTrials Research, Inc. Sandra Beyer (404)851-9934
IA Iowa City University of Iowa Karen Smith (319)353-5158
IL Chicago Rush University Medical Center David Sedillo (312)942-2633
IL Springfield Southern Illinois University Barbara Lokaitis (217)545-9737
IN Elkhart Indiana Medical Research, LLC Kay Stanley (574)296-3905
IN Indianapolis Indiana University Lauren Perrey (317)963-7505
KS Fairway University of Kansas Annette Becker (913)588-0555
KY Lexington University of Kentucky Keisha Jones (859)323-5550
LA Baton Rouge Pennington Biomedical Research Center Erin LeJeune (225)763-2706
MA Boston Boston University Jane Mwicigi (617)638-5670
ME Bangor Acadia Hospital and Eastern Maine Medical Center Claudine Allen (207)973-9013
MI Ann Arbor University of Michigan, Ann Arbor Jamie Guyot (Miller) (734)936-8036
MI Ann Arbor University of Michigan, Ann Arbor Kathryn Steen (734)615-5495
MI East Lansing Michigan State University Monica Gruber (517)884-2286
MI Kalamazoo Bronson Lakeview Hospital Gail Massey (269)341-8774
NC Winston-Salem Wake Forest University Health Sciences Maria Edelhauser (336)713-8823
NE Omaha University of Nebraska Medical Center Renee Hogue (402)552-6233
NJ Princeton Princeton Medical Institute Karleen Shim-Chim (609)921-3555 ext 11
NV Las Vegas Cleveland Clinic Lou Ruvo Center for Brain Health Yolande Mucharbach (702)483-7070
NY Amherst Dent Neurologic Institute Caroline Kumm (716)558-3492
NY New York Columbia University Ruth Tejeda (212)305-7661
NY New York Mount Sinai School of Medicine Florence Lau (212)659-8885
NY Orangeburg Nathan Kline Institute for Psychiatric Research Raymundo Hernando (845)398-5578
NY Rochester University of Rochester Medical Center Susan Salem-Spencer (585)760-6562
NY Syracuse SUNY Upstate Medical University Courtney Goodrich (315)464-6409
OH Beachwood Case Western Reserve University Susie Sami (216)464-6467
OK Tulsa Tulsa Clinical Research Christy Lisenbee (918)743-2349
PA Philadelphia University of Pennsylvania Martha Combs (215)615-3084
PA Pittsburgh University of Pittsburgh Thomas Baumgartner (412)692-2716
PA Willow Grove Abington Neurological Associates Priscilla Wong (215)957-9250 ext 6
SC Charleston Roper St. Francis Hospital Ric Freeman (843)724-2205
TN Nashville Vanderbilt Memory & Alzheimer’s Center Renée Martin-Willett (615)322-9007
TX Forth Worth University of North Texas Health Science Center Kimberly Brown (817)735-2694
TX Houston Houston Methodist Neurological Institute Jennifer Garrett (713)441-9484
WI Madison University of Wisconsin Matthew Gilles (608)262-3456
WI Waukesha Independent Psychiatric Consultant Anne Dobratz (262)513-0700