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This study is on a temporary enrollment hold. We will post here when enrollment begins again.

Study of Nasal Insulin to Fight Forgetfulness

A Multi-Center, Double-Blind, Placebo-Controlled Phase II/III Study to Evaluate the Impact of Nasal Inhaled Insulin in Participants with Mild Memory Impairment and early Alzheimer’s Disease.

What is the SNIFF study?

The purpose of the SNIFF study is to find out whether a type of insulin, when administered as a nasal spray, improves memory in adults with a mild memory impairment or Alzheimer’s disease (AD). The rationale behind the study is growing evidence that insulin carries out multiple functions in the brain and that poor regulation of insulin may contribute to the development of AD. Insulin resistance, reduced cerebrospinal fluid insulin levels, and reduced brain insulin signals have been found in AD patients, suggesting that a therapy aimed at correcting these deficiencies may be beneficial.

In this study participants will be given a nasal spray device with either insulin or placebo. Participants will be randomly assigned to the treatment or the placebo group for 12 months followed by six months in which all participants will receive insulin. During the first 12 months neither study participants nor study staff will know who is receiving active treatment and who is receiving placebo.

We are looking for 250 adults diagnosed with amnesiac mild cognitive impairment (aMCI) or early AD who would like to participate. The study will take place at about 30 research clinics nationwide.

Who will be eligible to participate?

Researchers will look for people age 55-85 who meet the following criteria:
  • Age 55-85
  • Have a diagnosis of aMCI or probable mild AD
  • Fluent in English or Spanish
  • Have a partner available to attend all clinic appointments and available to supervise drug administration twice a day
  • Stable medical condition for three months prior to screening visit
  • Stable medications for four weeks prior to screening visit
  • Do NOT take drugs for diabetes (type I or II)
  • Willing and able to undergo clinic assessments (for example -- blood and urine lab tests, MRI, lumbar puncture, ECG, neuropsychological tests)

For more information visit this web page later in the year for updates and enrollment information.

This study is being conducted by the Alzheimer’s Disease Cooperative Study (ADCS) through a grant from the National Institute on Aging (NIA), one of the National Institutes of Health (NIH).

Suzanne Craft, PhD is a Professor at the Wake Forest School of Medicine (Wake) in North Carolina. In 2012, Dr. Craft joined Wake as a Professor of Medicine following 18 years as faculty at the University of Washington.

Dr. Craft’s research investigates the role of insulin resistance and diabetes in the development of Alzheimer’s disease. Results of her team’s work include the identification of ways in which insulin resistance increases the risk of Alzheimer’s disease. Dr. Craft was awarded $7.9 million from the National Alzheimer’s Plan inaugural special fund to carry out a ground-breaking trial of intranasal insulin for the treatment of Alzheimer’s disease.

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Clinical Study Research Sites Participating in the SNIFF Study:

Banner Alzheimer's InstitutePhoenixAZ +602-839-6908
Howard UniversityWashingtonDC (202)865-3776
Georgetown UniversityWashingtonDC (202)687-0413
Mayo Clinic, JacksonvilleJacksonvilleFL (904)953-8014
University of South Florida - Health Byrd Alzheimer InstituteTampaFL (813)974-4904
Northwestern UniversityChicagoIL (312)503-2486
Indiana UniversityIndianapolisIN (317)963-7418
University of KansasKansas CityKS (913)945-7676
University of KentuckyLexingtonKY (859)323-3145
Brigham and Women's HospitalBostonMA (617)732-8085
Johns Hopkins UniversityBaltimoreMD (410)550-9053
Mayo Clinic, RochesterRochesterMN (507)293-4726
Washington University, St. LouisSt. LouisMO (314)286-2683
Wake Forest University Health SciencesWinston-SalemNC (336)713-8847
New York University Medical CenterNew YorkNY (212)263-5845
New York University Medical CenterNew YorkNY (212)263-5845
University of Rochester Medical CenterRochesterNY (585)760-6562
Case Western Reserve UniversityClevelandOH (216)464-6474
Oregon Health & Science UniversityPortlandOR (503)494-9399
Rhode Island HospitalProvidenceRI (401)444-2484
Roper St. Francis HospitalCharlestonSC (843)724-2302 ext 6370
University of Texas, Southwestern MC at DallasDallasTX (214)648-9331
Baylor College of MedicineHoustonTX (713)798-8329
University of WashingtonSeattleWA (206)764-2339