If you are interested in utilizing ADCS trial data, please review the ADCS Data Access Policy and  ADCS–Publication/Manuscript Citations Policy.

Access to ADCS trial data remains restricted until the study’s primary manuscript has been published. For the first year following publication, the study’s data is available only to members of the ADCS Steeering Committee. After that time, any investigator may request the data.

 

To request the data, complete the Data Access Request Form and submit to ADCSdataaccess@ucsd.edu.

Protocol Number
Protocol Name
Study Duration
Treatment
Diagnostic Group(s)
Instruments/Biomarkers
Actual Baselined
Paper Publication Date
Data Portal Status
ADC-001Selegiline(SL)24 mosSelegiline or a-Tocopherol or Selegiline Placebo and a-tocopherol or Selegiline and a-tocopherol Placebo or Placebo AD ADASCog, Blessed DRS, Blindness Eval, CDR, CERAD, ADL & Dependency Scale, Hackinski, MMSE, Modified UPDRS BL=341 04/1997
(Link to Pubmed)
Closed
ADC-002 New Instruments Trial(IN) 12 mos Non-Drug Study AD, NL ADL, CDR, CERAD, CGIC, CMAI, Hachinski, Executive Function, Facial Recognition, Letter Cancellation, Functional Assessment Staging, GDS, MMSE, Praxis, Severe Impair-ment Battery, Verbal Memory Immediate & Delayed Recall BL=306 06/1997
(Link to Pubmed)
Closed
ADC-002 New Instruments Trial (Spanish)(IN) 12 mos Non-Drug Study AD, NL ADL, CDR, CERAD, CGIC, CMAI, Hachinski, Executive Function, Facial Recognition, Letter Cancellation, Functional Assessment Staging, GDS, MMSE, Praxis, Severe Impair-ment Battery, Verbal Memory Immediate & Delayed Recall BL=94 06/1997
(Link to Pubmed)

Closed
ADC-003 Agitation(AP)24mos Haloperidol or Trazodone or Behavior Techniques or Placebo ADAPOE, Abnormal Involuntary Movement Scale, Blindness Eval, CGIC, CMAI, CERAD, CMAI, Hackinski, MMSE, Lawton and Brody ADL BL=149 11/2000
(Link to Pubmed)
Closed
ADC-004 Prednisone(PR)68wksPrednisone or Placebo ADADASCOG, ADASRECALL, ADAS RECOGNITION, APOE, Blessed Dimentia Rating, BPRS, Blindness Eval, CDR, Dependency Scale, HDRS, Hachinski, Lumbar, MMSE, UPDRS BL=138 02/2000
(Link to Pubmed)
Closed
ADC-005 Estrogen(ES)12mos + 3mos wash-outEstrogen(Premarin) or PlaceboADADASCog, ADASRECALL, ADAS RECOGNITION, APOE, Blindness Eval, BDRS, CDR, CSF, CGIC, Dependence Scale, Emotional Recognition, Hachinski, Hamilton, Lumbar Puncture, MAACL, MMSE, Newdot, QOL, Trailpeg, UPDRS BL=120 02/2000
(Link to Pubmed)
Closed
ADC-007 Melatonin(ML)8wks + 2wks placebo wash-outMelatonin or Placebo ADADASCog, ADAS RECOGNITION, ADASRL, ADL, APOE, Blindness Eval, COSTINF, EMOTION, Hamilton, Hachinski, MMSE, NPI, Parasomnia Questionnaire, QOL, Sleep Disorder Inv, UPDRS BL=15711/2003
(Link to Pubmed)
Closed
ADC-008 Mild Cognitive Impairment(MCI)36mos + 4mos donepezil visitsVitamin E or Donepezil HCL (Aricept) or Placebo MCIADACog, ADL, APOE/DNA Storage, Beck, Blindness Eval,MCI-CGIC, CDR, CT/MRI, GDS, Hamilton, Hachinski, Logical Memory I and II, MMSE, Neuropsychological Battery, Oxidative Biomarkers/DNA Storage, QOL, RUI BL=76906/2005
(Link to Pubmed)
Closed
ADC-010 Normal Control(NL)36mosNon-Drug StudyNLADACog, ADL, APOE/DNA Storage, Beck, Blindness Eval, Cleveland QOL, CGIC, CDR, GDS, Hamilton, Hachinski, Logical Memory I and II, MMSE, Neuropsychological Battery, QOL, RUITarget Enrollment=100PendingClosed
ADC-011 NSAIDS/Non-Steroidal(NS)12mos + 2mos wash-out Vioxx (Rofecoxib)25 mg or Alleve (Naproxen) 200 mg or Placebo ADADASCog, ADL, APOE/DNA, Blindness Eval, CDR, CT/MRI, Hachinski, MMSE, NPI, QOL, RUI BL=35106/2003
(Link to Pubmed)
Closed
ADC-012 Valproate(VP)6wks + 6wks open label Divalproex Sodium or Placebo ADBPRS, CMAI, Hachinski, MMSE BL=15311/2005
(Link to Pubmed)
Closed
ADC-013Prevention
Instruments(PI)
48 mosNon-Drug StudyMCI, NLADL, APOE/DNA Storage, Behavioral Scale, Boston Naming, CDR, CGIC-IRPV, CGIC-SAPV, Cognitive Scale, Efficiency, Free and Cued Selective Reminding, GDS, Cognitive Function Screening Instruments, QOL, MMSE, NPI, NYU Paragraph, RUI, Trails A & B and WAIS-R BL=662PendingClosed
ADC-013Prevention Instruments - Web Based(PIWEB) 48mosNon-Drug StudyMCI, NLADL, APOE/DNA Storage, Behavioral Scale, Boston Naming, CDR, CGIC-IRPV, CGIC-SAPV, Cognitive Scale, Efficiency, Free and Cued Selective Reminding, GDS, Cognitive Function Screening Instruments, QOL, MMSE, NPI, NYU Paragraph, RUI, Trails A & B and WAIS-R BL=55 PendingClosed
ADC-014 TAP/DAP of Diffuse Lewy Body10wksQuetiapine(Seroquel) or Donepezil (Aricept) or Quetiapine and Donepezil or PlaceboAD, DLBADL, BPRS, CGIC, MMSE, NPI, R-MDS-D, UPDRS BL=4004/2007
(Link to Pubmed)
Closed
ADC-015 Simvastatin(LL)18mosSimvastatin or Placebo ADADASCog, APOE/DNA Storage, Blindness Eval ,CGIC, Dependency Scale, Hachinski, MMSE, NPI, QOL, RUI BL=40608/2011
(Link to Pubmed)
Closed
ADC-016 Homocysteine(HC) 18mosFolate, Vitamin B6, Vitamin B12 or Placebo ADADASCog, ADL, APOE/DNA Storage, Blindness Eval, CDR, CT/MRI, Hachinski, QOL, MMSE, NPI, RUI BL=40910/2008
(Link to Pubmed)
Closed
ADC-022 Valproate Neuroprotection(VN)24mos + 2mos wash-out Valproate or Placebo ADADL, ADASCog, APOE, CDR, CGIC, Biomarker, ClinEval, CDR, CMAI, CT/MRI, Family History, MMSE, NPI, QOL BL=31308/2011
(Link to Pubmed)
Closed
ADC-023 Huperzine(HU) 24wks + open label Phase I up to 48wks + open label Phase II up to 72 wks Huperzine A or Placebo ADADASCog, ADL, Blindness Eval, CGIC, CT/MRI, Hachinski, MMSE, NPI BL=21004/2011
(Link to Pubmed)
Closed
ADC-025 Antioxidant(AX)16wks + follow-up phone callVitamin E plus Vitamin C plus a-Lipoic Acid and Coenzyme Q, or PlaceboADADL, Biomarkes, BPRS, GDS, Hachinski, Lumbar Puncture, MMSE BL=7807/2012
(Link to Pubmed)
Closed
ADC-027 Docosahexaenoic Acid(DHA) 18mosDocosahexaenoic Acid or PlaceboADADAS-Cog, ADCS-ADL, APOE, CDR-SOB, FFQ, Hachinski, Lumbar puncture, MMSE, MRI, NPI, QOL BL=40211/2010
(Link to Pubmed)
Closed